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Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

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[The effects of hyperventilation upon spinal dorsal horn neuronal single-unit activities under nitrous oxide

Yasuo Ide¹, Megumu Tagami, Toshinobu Sumida

¹Department of Anesthesiology, Toho University Sakura Hospital, Sakura.

Masui. the Japanese Journal of Anesthesiology

|July 20, 2005

Abstract

Background:

The purpose of this study is to investigate the effects of hyperventilation upon spinal dorsal horn neuronal single-unit activities under nitrous oxide anesthesia.

Methods:

Eight decerebrated spinal cats with laminectomy were maintained with oxygen and pancuronium bromide. Following the control period of normocapnia, 50% nitrous oxide was administered for 30 minutes after a hypocapnia period of 20-25 mmHg for 20 minutes. The recoveries of activities followed with normocapnia and pure oxygen administration. The changes of spontaneous and evoked activities by the pinching were investigated every 5 minutes after control study.

Results:

Inhalation of 50% nitrous oxide suppressed the WDR neuronal activities and with hyperventilation the suppressions significantly increased.

Conclusions:

These results were compatible with clinical reports on the effectiveness of hyperventilation as a maintenance method under N2O anesthesia.

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