Just the two of us: melatonin and adenosine in rodent pituitary function

The function of the pituitary gland is tightly controlled by neuronal and hormonal afferents of the brain. In this review, the role of the neurohormone melatonin and the neuromodulator adenosine for rodent pituitary function will be elucidated. Adenosine is known as an important paracrine modulator for pituitary endocrine and folliculostellate cells, with availability regulated by local metabolic cellular activity. In general, adenosine inhibits the cyclic adenosine monophosphate (AMP) pathway in pituitary cells by binding to A1-, and A3-adenosinergic receptors, and activates it via A2-adenosinergic receptors. The neurohormone melatonin integrates time-of-day and time-of-year into pituitary function via binding to MT1-melatonin receptors. Melatonin impacts at the hypothalamic level neurons that synthesize releasing and release-inhibiting hormones, and at the pituitary level only cells of the hypophyseal pars tuberalis (PT). Thereby, the daily changes in the duration of the nocturnal melatonin surge are decoded and subsequently relayed to the pars distalis to adapt gonadotropin and prolactin release, respectively, to season. An exciting integration of time within the regulation of pituitary function was deciphered by analysing transmembrane signalling events in cells of the hypophyseal PT: a consecutive daily impact of initially the neurohormone melatonin and later the neuromodulator adenosine on rodent PT cells leads to a circadian rhythm in the transcription of cyclic-AMP-sensitive genes.