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Impairment of cardiac function in hypertensive patients with Type 2 diabetes: a LIFE study

P Hildebrandt1, K Wachtell, B Dahlöf

  • 1Frederiksberg University Hospital, Frederiksberg, Denmark. ph@fh.hosp.dk

Diabetic Medicine : a Journal of the British Diabetic Association
|July 20, 2005
PubMed

Insights

Type 2 diabetes impairs cardiac function in hypertensive patients with left ventricular hypertrophy, independent of increased heart muscle mass. Diabetes itself adversely affects both systolic and diastolic heart function.

Area of Science:

  • Cardiology
  • Diabetology
  • Hypertension Research

Background:

  • Type 2 diabetes and hypertension commonly coexist.
  • Hypertension leads to increased left ventricular (LV) mass and impaired cardiac function.
  • The independent contribution of diabetes to cardiac dysfunction in hypertensive patients with LV hypertrophy is unclear.

Purpose of the Study:

  • To compare LV function between diabetic and non-diabetic hypertensive patients with electrocardiographic LV hypertrophy.
  • To determine if impaired cardiac function is solely due to LV hypertrophy or independently related to diabetes.

Main Methods:

  • Analysis of echocardiograms from 937 patients in the LIFE echocardiographic substudy.
  • Centralized evaluation of LV mass, systolic, and diastolic LV function.
  • Comparison between 105 diabetic patients and non-diabetic hypertensive patients.

Main Results:

  • Left ventricular mass was similar between diabetic and non-diabetic groups.
  • Diabetic patients showed reduced endocardial systolic function (LV ejection fraction) and impaired midwall systolic function.
  • Diastolic LV filling was impaired, and arterial stiffness was increased in diabetic patients.

Conclusions:

  • Cardiac systolic and diastolic function are impaired in hypertensive patients with LV hypertrophy and diabetes.
  • These impairments are independent of LV mass.
  • The findings suggest adverse effects of diabetes per se on cardiac function.
Abstract

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