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Updated: Aug 16, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
Pathophysiological basis of drug-induced dyskinesias in Parkinson's disease
Milind Deogaonkar1, Thyagarajan Subramanian
1Department of Neuroscience, NB 20, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. deoganm@ccf.org
Abstract:
Drug-induced dyskinesias (DID) represent a troublesome, dose-limiting, and common complication of long-term pharmacotherapy in Parkinson's disease (PD) patients. The pathophysiological basis and clinical nature of DID is of major interest for clinicians and neuroscientists. In this review article, we evaluate the theories of pathophysiology and molecular basis of DID, validity of various animal models used in DID related research, and electrophysiological characteristics of various basal ganglia nuclei during DID. We also discuss the relevance of various treatment strategies to the pathophysiological mechanisms.
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