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Related Experiment Video

Updated: Jul 21, 2026

Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo
13:07

Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo

Published on: December 5, 2012

Long-term spinal reflex studies in awake behaving mice.

Jonathan S Carp1, Ann M Tennissen, Xiang Yang Chen

  • 1Wadsworth Center, New York State Department of Health, PO Box 509, Albany, NY 12201-0509, USA. carpj@wadsworth.org

Journal of Neuroscience Methods
|July 20, 2005
PubMed
Summary

Researchers developed a new method for continuous, long-term electromyographic (EMG) recording in mice. This technique allows for detailed analysis of motor commands during behavior, advancing neurophysiological and behavioral studies.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Animal Models

Background:

  • Genetic mouse models are crucial for studying molecular roles in behavior.
  • Integrating motor command data with genetic studies requires robust recording methods.
  • Existing long-term electromyographic (EMG) recording methods in mice are not continuous.

Purpose of the Study:

  • To develop and validate a method for continuous, long-term EMG recording in freely moving mice.
  • To enable detailed analysis of spontaneous and nerve-evoked EMG.
  • To support correlative studies between genetic variations, behavior, and motor control.

Main Methods:

  • Fabrication and implantation of fine wire EMG electrodes and a tibial nerve cuff electrode in mice.
  • Continuous 24/7 computer-monitored EMG recording for extended periods (18-92 days).

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Terminal H-reflex Measurements in Mice
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Related Experiment Videos

Last Updated: Jul 21, 2026

Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo
13:07

Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo

Published on: December 5, 2012

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
11:13

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Published on: November 29, 2013

Terminal H-reflex Measurements in Mice
05:38

Terminal H-reflex Measurements in Mice

Published on: June 16, 2022

  • Automated nerve stimulation to evoke M-responses (MR) and H-reflexes (HR), with real-time adjustment of stimulation intensity.

    • Main Results:

    • Successful long-term (59-144 days post-implantation) continuous EMG recordings were achieved.
    • Stable recordings of ongoing EMG, MR, and HR were typically obtained within 3 weeks post-implantation.
    • Demonstrated feasibility of monitoring both spontaneous muscle activity and evoked responses.

    Conclusions:

    • The developed fine wire electrode system enables continuous, long-term EMG recordings in mice.
    • This methodology is suitable for investigating neurophysiological and behavioral questions in freely moving animals.
    • Advances the ability to correlate genetic data with detailed motor command patterns.