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Updated: Aug 16, 2026
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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
Identification of broad specificity P450CAM variants by primary screening against indole as substrate
Ayhan Celik1, Robert E Speight, Nicholas J Turner
1School of Chemistry, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, UKEH9 3JJ. n.j.turner@ed.ac.uk
Chemical Communications (Cambridge, England)
|July 20, 2005
Abstract:
High-throughput screening of cytochrome P450CAM libraries, for their ability to oxidise indole to indigo and indirubin, has resulted in the identification of variants with activity towards the structurally unrelated substrate diphenylmethane.
