Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Identifying and mapping surface amorphous domains.

Stuart Ward1, Mark Perkins, Jianxin Zhang

  • 1Molecular Profiles Ltd., 8 Orchard Place, Nottingham Business Park, Nottingham, NG8 6PX, UK.

Pharmaceutical Research
|July 20, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of an efficient approach to boost fused deposition modeling (FDM) printing of felodipine-HPMC tablets for enhanced physical stability.

International journal of pharmaceutics: X·2025
Same author

High-Throughput Microarray Approaches for Predicting the Stability of Drug-Polymer Solid Dispersions.

Molecular pharmaceutics·2024
Same author

The Anti-atherosclerosis Mechanism of Ziziphora clinopodioides Lam. Based On Network Pharmacology.

Cell biochemistry and biophysics·2023
Same author

Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers.

Pharmaceutical development and technology·2023
Same author

Dietary Bacillus velezensis R-71003 and sodium gluconate improve antioxidant capacity, immune response and resistance against Aeromonas hydrophila in common carp.

Fish & shellfish immunology·2023
Same author

Daytime-restricted feeding enhances running endurance without prior exercise in mice.

Nature metabolism·2023
Same journal

Design, Synthesis and Characterization of Anti-CTLA4 Peptide Conjugated Gemcitabine Prodrug Nanoparticles for Targeted Lung Cancer Chemoimmunotherapy.

Pharmaceutical research·2026
Same journal

Leveraging Carnitine-functionalized Lipid Nanocarrier based Targeted Delivery of A1874 PROTAC for Glioblastoma.

Pharmaceutical research·2026
Same journal

Impact of Febrile State on Vancomycin Clearance in Pediatric Patients: Insights From Population Pharmacokinetic Modeling.

Pharmaceutical research·2026
Same journal

Sustained Intra-Articular Delivery of Triple Therapeutics Using a Phase-Transition Phospholipid-Based Gel for Effective Treatment of Gouty Arthritis.

Pharmaceutical research·2026
Same journal

Spray Dried Lysozyme Microspheres: Morphological Evolution and Enzymatic Activity Retention.

Pharmaceutical research·2026
Same journal

Colloidal Stability of Amorphous Nanoparticles in Solution: Impact of Stabilizer.

Pharmaceutical research·2026
See all related articles

This study presents methods to detect and map surface amorphous material, crucial for pharmaceutical formulation. Atomic force microscopy and Raman microscopy effectively characterize amorphous content in semicrystalline solids.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Analytical Chemistry

Background:

  • Amorphous material generation during pharmaceutical formulation can lead to significant problems.
  • Surface amorphous material is particularly important in drug delivery systems due to interfacial properties.

Purpose of the Study:

  • To investigate methods for detecting and mapping surface amorphous material.
  • To address the significance of interfacial properties in drug delivery systems.

Main Methods:

  • Generation of amorphous sorbitol domains using localized heating.
  • Investigation using atomic force microscopy (AFM) imaging and nanomechanical measurements.
  • Characterization using Raman microscopy for 3-D profiling.

Related Experiment Videos

Main Results:

  • AFM revealed nanoscale variations in both crystalline and amorphous sorbitol.
  • Nanomechanical measurements quantitatively distinguished amorphous and crystalline domains via Young's modulus.
  • Raman microscopy differentiated phases by peak width, enabling 3-D amorphous phase mapping.

Conclusions:

  • AFM and Raman microscopy provide submicron resolution for mapping surface amorphous material distribution.
  • These techniques demonstrate effective surface analysis for semicrystalline solids in pharmaceutical processing.