Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffusion tensor imaging of the human optic nerve using a non-CPMG fast spin echo sequence.

Steren Chabert1, Nicolas Molko, Yann Cointepas

  • 1SHFJ/CEA, #4 Place du Général Leclerc, 91401 Orsay, France.

Journal of Magnetic Resonance Imaging : JMRI
|July 20, 2005
PubMed
Summary

Researchers developed a new imaging technique to study the human optic nerve in vivo. This method provides reliable diffusion-weighted images, potentially aiding in the diagnosis of optic nerve conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synaptic micromechanics and brain softening as a mechanobiological hypothesis for Alzheimer's disease.

Frontiers in neuroscience·2026
Same author

Impact of Age-Related Hearing Loss on Brain Connectivity and Cognitive Performance: A Systematic Review.

Trends in hearing·2026
Same author

Beyond binary classification: a pilot study of imaging-derived glioma severity modeling using T1-weighted and diffusion MRI radiomics.

Magma (New York, N.Y.)·2026
Same author

Singing in the brain.

Japanese journal of radiology·2026
Same author

Potential of the signature index (S-index), a diffusion MRI Biomarker, to enhance diagnosis of clinically significant prostate cancer and decrease the rate of unnecessary biopsies.

European journal of radiology·2026
Same author

Towards Clinical Translation of Intravoxel Incoherent Motion MRI: Acquisition and Analysis Consensus Recommendations.

Journal of magnetic resonance imaging : JMRI·2026

Area of Science:

  • Neuroimaging
  • Diffusion Tensor Imaging
  • Magnetic Resonance Imaging

Background:

  • Diffusion tensor imaging (DTI) is crucial for assessing white matter integrity.
  • Traditional DTI methods face challenges in the orbital region due to magnetic field inhomogeneities.
  • Artifacts in orbital DTI can hinder accurate diagnosis of optic nerve pathologies.

Purpose of the Study:

  • To evaluate diffusion tensor properties of the human optic nerve in vivo.
  • To utilize a novel non-Carr-Purcell-Meiboom-Gill (CPMG) fast spin echo (FSE) sequence for optic nerve imaging.
  • To overcome limitations of conventional DTI in the orbital area.

Main Methods:

  • Employed a non-CPMG FSE sequence with quadratic phase modulation of refocusing pulses.
  • Acquired diffusion measures with full signal and minimized geometric distortion artifacts.

Related Experiment Videos

  • Achieved high-resolution imaging at 0.94 x 0.94 x 3 mm.

    • Main Results:

    • Obtained good-quality diffusion-weighted images of the human optic nerve.
    • Measured mean diffusivity (MD) of 1.1 +/- 0.2 x 10(-3) mm(2)/second.
    • Determined fractional anisotropy (FA) of 0.49 +/- 0.06, indicating optic nerve anisotropy.

    Conclusions:

    • The non-CPMG-FSE sequence offers reliable diffusion-weighted imaging of the optic nerve.
    • This technique shows promise for improved diagnosis and management of optic nerve diseases.
    • Potential applications include conditions like optic neuritis, orbit tumors, and muscle hypertrophy.