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Spiral coronary angiography using a blood pool agent

Steffen Ringgaard1, Michael Pedersen, Jonas Rickers

  • 1MR Center, Institute of Clinical Medicine, Skejby Sygehus, Aarhus University Hospital, Brendstrupgaardsvej 100, DK-8200 Aarhus N., Denmark. steffen@mr.au.dk

Journal of Magnetic Resonance Imaging : JMRI
|July 20, 2005
PubMed
Abstract

Insights

This study found that low doses of iron oxide contrast agents improve coronary MRA image quality. Single spiral excitations yielded better results than triple excitations, with higher concentrations negatively impacting image quality due to T2* effects.

Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Pharmacology

Background:

  • Coronary artery disease (CAD) diagnosis relies on accurate imaging.
  • Iron oxide blood pool agents offer potential for enhanced Magnetic Resonance Angiography (MRA).
  • Optimizing contrast agent dosage and acquisition parameters is crucial for diagnostic image quality.

Purpose of the Study:

  • To determine the optimal dose of an iron oxide blood pool agent for coronary MRA.
  • To compare image quality using single versus multiple spiral excitations per cardiac cycle.

Main Methods:

  • Eight pigs underwent spiral coronary MRA in late diastole.
  • Inversion prepulse and increasing doses of iron oxide agent (0.8, 2.2, 3.9 mg Fe/kg) were used.
  • Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured for single and triple spiral excitations.

Main Results:

  • A significant increase in SNR and CNR was observed at 0.8 mg Fe/kg for both single and triple excitations.
  • Increasing the dose to 2.2 mg Fe/kg further improved SNR, but not CNR.
  • Single excitations consistently yielded higher SNR and CNR compared to triple excitations across all concentrations (P < 0.05).

Conclusions:

  • Iron oxide blood pool agents effectively enhance SNR and CNR in spiral coronary MRA at low concentrations.
  • Single spiral excitations provide superior image quality compared to multiple excitations.
  • Higher iron oxide concentrations can degrade image quality due to T2* effects.

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