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Studies on the mechanisms of HTLV-I leukemogenesis
D Saggioro1, F Majone, M Forino
1Institute of Oncology, University of Padova, Italy.
Leukemia
|January 1, 1992
Abstract:
The factors that regulate low viral expression and long latency after HTLV-I infection are poorly understood. To study the possible mechanisms involved in the regulation of gene expression and cell transformation, we studied whether (1) methylation could play a role in viral transcription, and (2) tax product could favor chromosomal instability. The results indicate that methylation of HTLV-I LTRs blocks their transcriptional activity and that tax protein triggers DNA damage.