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Interaction of large granular lymphocytes with susceptible target does not induce second messenger and cytolytic
1Institute of Oncology, Inter-University Center for Cancer Research, University of Padova, Italy.
Leukemia
|January 1, 1992
Abstract:
We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.