Related Experiment Video
Updated: Aug 16, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
Delayed clearance of fetal lung liquid and sodium transport--genetic predisposition not evident yet
1Department of Paediatrics, University of Oulu, Oulu, Finland. mikko.hallman@oulu.fi
Unlabelled:
The epithelial Na+ channel (ENaC) contributes to the clearance of fetal lung liquid. In premature infants, low ENaC activity and low expression level of alpha-ENaC have been associated with respiratory failure. The polymorphism in the alpha-ENaC gene remains to be studied as a factor explaining the variation in the incidence of transient tachypnoea or respiratory distress syndrome in the newborn.
Conclusion:
The study of genetic predisposition to common multifactorial diseases requires analyses of large, well-defined cohorts for representative variants of relevant candidate genes.
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