Related Experiment Video

Updated: Jul 14, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

CD64 (Fcgamma receptor I) cell surface expression on maturing neutrophils from preterm and term newborn infants

G Fjaertoft1, L Håkansson, T Foucard

  • 1Department of Women's and Children's Health, Section of Paediatrics, University Hospital, Uppsala, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|July 21, 2005
PubMed

Insights

Neutrophil CD64 (FcgammaRI) expression is moderately increased in preterm infants at birth, potentially aiding bacterial infection diagnosis. This expression normalizes within the first month, unaffected by preterm birth complications like RDS or PROM.

Area of Science:

  • Immunology
  • Neonatal Research
  • Infectious Disease Diagnostics

Background:

  • Neutrophil CD64 (FcgammaRI) expression elevates during bacterial infections, suggesting diagnostic potential in infants.
  • Understanding CD64 dynamics in newborns is crucial for early infection detection.

Purpose of the Study:

  • To monitor changes in neutrophil CD64 expression postpartum in infants.
  • To assess the influence of respiratory distress syndrome (RDS) and preterm rupture of membranes (PROM) on CD64 expression.

Main Methods:

  • Flow cytometry analyzed CD64, CD32, CD16, CD11b/CD18, and CD35 expression on neutrophils from preterm/term infants and adults.
  • Comparative analysis of Fcgamma and complement receptor expression.

Main Results:

  • Preterm infants exhibit moderately increased neutrophil CD64 at birth, decreasing to term/adult levels within one month.
  • Neutrophil CD32 and CD16 expression were lower in preterm infants compared to term infants and adults.
  • CD11b expression was similar across groups but increased post-birth in newborns.

Conclusions:

  • Neutrophil CD64 is moderately elevated in preterm infants at birth, likely indicating bacterial infection rather than preterm birth complications.
  • CD64 expression appears independent of RDS and PROM, reinforcing its specificity for bacterial infections.
Abstract

More Related Videos

Rapid Magnetic-microbead Method for Efficient Purification of Low-density Neutrophils08:14

Rapid Magnetic-microbead Method for Efficient Purification of Low-density Neutrophils

Published on: November 11, 2025

Mapping Infant Immunity with Minimal Input: Integrative Single-Cell and Multiomic Profiling10:29

Mapping Infant Immunity with Minimal Input: Integrative Single-Cell and Multiomic Profiling

Published on: April 3, 2026

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...