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Selection of candidate genes in hypertension
Charles A Mein1, Mark J Caulfield, Patricia B Munroe
1The Genome Centre and Clinical Pharmacology, The William Harvey Research Institute, Barts and The London, Charterhouse Square, London, UK.
Abstract:
Essential hypertension is a common disease with multifactorial etiology affecting up to 10 million individuals in the United Kingdom alone. Current knowledge of the genetic contribution to this trait is restricted to a number of rare variants that produce hypertensive phenotypes in a Mendelian fashion and to genes highlighted by work on blood pressure regulation in rodent models. Recent advances in comparative genomics, genome-wide scans for linkage, transcriptomics, proteomics, and metabolomics allow a systematic approach to the prioritization of candidate genes for hypertension and other complex traits. We review the current state of play in these fields related to hypertension and show, with a particular example, how these data may help target genetic studies in the future.
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