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Published on: May 17, 2012
Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties
Shyam M Rele1, Wanxing Cui, Lianchun Wang
1Department of Surgery, Emory University, and School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30322, USA.
Abstract:
A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 103-fold greater activity than other multivalent sLex glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed in vivo.
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