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N-Channel field-effect transistors with floating gates for extracellular recordings
Sven Meyburg1, Michael Goryll, Jürgen Moers
1Institute of Thin Films and Interfaces and Center of Nanoelectronic Systems, Bio- and Chemosensors (ISG2), Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany.
Biosensors & Bioelectronics
|July 21, 2005
Summary
This study introduces a novel floating gate field-effect transistor (FET) for robust extracellular signal recording from electrogenic cells. The device demonstrates lower noise and reusable capabilities, paving the way for advanced cellular monitoring.
Area of Science:
- Biomedical Engineering
- Materials Science
- Neuroscience
Background:
- Extracellular signal recording from electrogenic cells is crucial for understanding cellular function.
- Existing field-effect transistor (FET) technologies have limitations in separate optimization of transistor and sensing capabilities.
- Complementary metal-oxide-semiconductor (CMOS) technology offers potential for integrated biosensing platforms.
Purpose of the Study:
- To develop and characterize a novel floating gate FET architecture for enhanced extracellular signal recording.
- To evaluate the performance of the developed FETs using cardiac myocytes and assess their suitability for physiological measurements.
- To explore the integration potential of this technology within a CMOS fabrication process for advanced biosensor development.
Main Methods:
- Fabrication of floating gate FETs utilizing standard CMOS n-channel transistor processes.
- Characterization of device noise levels and robustness, including reusability.
- Extracellular recording of action potentials from embryonic rat cardiac myocytes before and after isoproterenol stimulation.
Main Results:
- The floating gate FETs exhibited lower noise levels compared to non-metallised gate FETs.
- Devices demonstrated robustness and reusability for multiple recordings.
- Recorded action potential shapes were comparable to previous studies, validating the device's efficacy for cellular signal detection.
- A long-term drift was observed, requiring further investigation for long-term applications.
Conclusions:
- The floating gate FET architecture offers a promising platform for extracellular signal recording with improved noise performance and reusability.
- The technology is compatible with CMOS fabrication, enabling future integration of signal processing circuits for multi-sensor applications.
- Further research is needed to address long-term drift for sustained physiological monitoring.