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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
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Interleukin-13 (IL-13) pathway

Ann Kelly-Welch1, Erica M Hanson, Achsah D Keegan

  • 1Program in Oncology, Marlene and Stewart Greenebaum Cancer Center and Department of Microbiology and Immunology, University of Maryland, Baltimore, USA.

Science'S STKE : Signal Transduction Knowledge Environment
|July 21, 2005
PubMed

Interleukin-13 (IL-13), like IL-4, is a cytokine produced by T(H)2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils. IL-13 induces many of the same responses as IL-4 and shares a receptor subunit with IL-4. IL-13 has been implicated in airway hypersensitivity and mucus hypersecretion, inflammatory bowel disease, and parasitic nematode expulsion.

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