Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin-13 (IL-13) pathway.

Ann Kelly-Welch1, Erica M Hanson, Achsah D Keegan

  • 1Program in Oncology, Marlene and Stewart Greenebaum Cancer Center and Department of Microbiology and Immunology, University of Maryland, Baltimore, USA.

Science'S STKE : Signal Transduction Knowledge Environment
|July 21, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harnessing nanomedicine and immunometabolism to treat allergic disease.

Nanomedicine (London, England)·2026
Same author

Impact of antigen loading in tolerogenic nanoparticles to mitigate Th2-mediated allergic lung inflammation.

Drug delivery and translational research·2024
Same author

Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins.

Frontiers in immunology·2024
Same author

M2a macrophages facilitate resolution of chemically-induced colitis in TLR4-SNP mice.

mBio·2023
Same author

Protection against influenza-induced Acute Lung Injury (ALI) by enhanced induction of M2a macrophages: possible role of PPARγ/RXR ligands in IL-4-induced M2a macrophage differentiation.

Frontiers in immunology·2022
Same author

Mice Expressing Cosegregating Single Nucleotide Polymorphisms (D298G and N397I) in TLR4 Have Enhanced Responses to House Dust Mite Allergen.

Journal of immunology (Baltimore, Md. : 1950)·2022

Interleukin-13 (IL-13) is a cytokine involved in immune responses, similar to IL-4. It plays a role in conditions like asthma and inflammatory bowel disease.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Interleukin-13 (IL-13) is a cytokine produced by T helper 2 cells, mast cells, basophils, and eosinophils.
  • IL-13 shares functional similarities and a receptor subunit with Interleukin-4 (IL-4).

Purpose of the Study:

  • To summarize the known functions and implications of IL-13 in various biological processes and diseases.

Main Methods:

  • Literature review and synthesis of existing research on IL-13.
  • Analysis of IL-13's role in immune cell activation and signaling pathways.

Main Results:

  • IL-13 induces responses similar to IL-4.
  • IL-13 is implicated in allergic airway inflammation, mucus overproduction, inflammatory bowel disease, and defense against parasitic worms.

Related Experiment Videos

Conclusions:

  • IL-13 is a key mediator in Th2-driven immune responses.
  • Understanding IL-13's functions is crucial for developing treatments for related inflammatory and allergic conditions.