Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental tuberculosis in red deer (Cervus elaphus).

G W de Lisle1, P J Welch, P F Havill

  • 1Animal Health Reference Laboratory, Wallaceville Animal Research Centre, Private Bag, Upper Hutt, New Zealand.

New Zealand Veterinary Journal
|December 1, 1983
PubMed
Summary

Experimental Mycobacterium bovis infection in red deer shows that intravenous inoculation leads to fatal miliary tuberculosis. Other routes, like subcutaneous and intratracheal, resulted in less severe disease, indicating inoculation route impacts infection control.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetics of bromoform in dairy heifers.

New Zealand veterinary journal·2024
Same author

Pain sensitivity and injury associated with three methods of disbudding goat kids: Cautery, cryosurgical and caustic paste.

Veterinary journal (London, England : 1997)·2018
Same author

Anal fibropapillomas containing bovine papillomavirus type 2 DNA in two groups of heifers.

New Zealand veterinary journal·2018
Same author

Systemic granulomatous and haemorrhagic syndrome in New Zealand dairy cattle.

New Zealand veterinary journal·2017
Same author

A 9-year retrospective evaluation of 102 pressure ulcer reconstructions.

Journal of wound care·2015
Same author

Toward eradication: the effect of Mycobacterium bovis infection in wildlife on the evolution and future direction of bovine tuberculosis management in New Zealand.

New Zealand veterinary journal·2014

Area of Science:

  • Veterinary Pathology
  • Infectious Diseases
  • Wildlife Health

Background:

  • Mycobacterium bovis causes tuberculosis in various animal species.
  • Red deer (Cervus elaphus) are susceptible to bovine tuberculosis.
  • Understanding infection routes is crucial for disease management in wildlife.

Purpose of the Study:

  • To investigate the effects of experimental Mycobacterium bovis infection in red deer.
  • To determine the influence of inoculation route on disease progression and severity.
  • To assess the pathological outcomes following different experimental infection methods.

Main Methods:

  • Red deer were experimentally infected with Mycobacterium bovis via intravenous, subcutaneous, and intratracheal routes.
  • Dose variations were administered for each inoculation route.

Related Experiment Videos

  • Animals were monitored for clinical signs, and post-mortem examinations were conducted.
  • Histopathological analysis and acid-fast bacilli staining were performed on tissues.

    • Main Results:

    • Intravenous inoculation (10-1000 microg) resulted in miliary tuberculosis and death within 28 days.
    • Subcutaneous and intratracheal inoculations did not cause immediate clinical illness.
    • Lesions varied with dose and route: intravenous led to severe lung pathology, subcutaneous showed dose-dependent lesions from injection site to liver, and intratracheal affected thoracic cavity.
    • All surviving deer reacted to purified protein derivative (PPD) at experiment conclusion.

    Conclusions:

    • The route of Mycobacterium bovis inoculation significantly influences disease outcome in red deer.
    • Intravenous inoculation is highly virulent, leading to rapid, fatal tuberculosis.
    • Subcutaneous and intratracheal routes may allow for controlled infection or localized disease, but systemic spread can occur with higher doses or specific routes.