Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Suspected selenium poisoning in a horse.

H F Dewes1, M D Lowe

  • 1Hamilton Analytical Laboratory, Hamilton East.

New Zealand Veterinary Journal
|April 1, 1987
PubMed
Summary

Selenium poisoning in a horse was suspected after high daily doses of sodium selenate. Clinical signs included hair loss and hoof separation, with excretion confirmed via blood, hair, and hoof analyses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcome of ACHD patients with non-inducible versus inducible IART undergoing cavo-tricuspid isthmus ablation: the role of empiric ablation.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·2020
Same author

Assessment of a conduction-repolarisation metric to predict Arrhythmogenesis in right ventricular disorders.

International journal of cardiology·2018
Same author

Safety and efficacy of multipolar pulmonary vein ablation catheter vs. irrigated radiofrequency ablation for paroxysmal atrial fibrillation: a randomized multicentre trial.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2014
Same author

High-density substrate mapping in Brugada syndrome: combined role of conduction and repolarization heterogeneities in arrhythmogenesis.

Circulation·2009
Same author

Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium.

Heart (British Cardiac Society)·2001
Same author

Comparison of central venous and inferior vena caval pressures.

The American journal of cardiology·2000

Area of Science:

  • Veterinary toxicology
  • Equine medicine
  • Mineral metabolism

Background:

  • Selenium is an essential trace element, but excessive intake can lead to toxicity.
  • Sodium selenate is a common source of supplemental selenium.
  • Understanding selenium excretion routes is crucial for diagnosing and managing toxicity.

Purpose of the Study:

  • To report a case of suspected selenium poisoning in a horse.
  • To identify the clinical signs associated with acute selenium toxicity.
  • To investigate the routes of selenium excretion in affected animals.

Main Methods:

  • Administration of a high dose of sodium selenate (325 micromol/day) to a horse for five consecutive days.
  • Clinical observation for signs of toxicity, focusing on integumentary changes.
  • Periodic analysis of blood, hair, and hoof parings to assess selenium levels and excretion.

Main Results:

  • The horse exhibited signs of selenium poisoning, including hair loss (mane and tail) and skin disintegration (anus, lips, prepuce, scrotum).
  • Hoof abnormalities were observed, such as separation of hooves from the coronary corium.
  • Analysis confirmed a strong correlation between blood selenium levels and selenium found in hair and hoof samples, indicating these as significant excretion routes.

Conclusions:

  • High-dose sodium selenate administration can induce acute selenium toxicity in horses.
  • Integumentary changes and hoof abnormalities are key clinical indicators of selenium poisoning.
  • Hair and hoof analyses are valuable diagnostic tools for confirming selenium toxicity and understanding excretion pathways.

Related Experiment Videos