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Persistent anthelmintic activity of topically administered ivermectin in cattle.
1Batchelar Animal Health Laboratory, PO Box 1654, Palmerston North.
New Zealand Veterinary Journal
|December 1, 1989
Summary
Topical ivermectin demonstrated persistent anthelmintic effects in calves. This treatment showed high efficacy against common gastrointestinal nematodes and lungworms for extended periods.
Area of Science:
- Veterinary Parasitology
- Pharmacology
Background:
- Parasitic infections caused by Ostertagia ostertagi, Trichostrongylus axei, and Dictyocaulus viviparus pose significant health challenges in calves.
- Effective and persistent anthelmintic treatments are crucial for calf health and productivity.
Purpose of the Study:
- To evaluate the persistent anthelmintic efficacy of topical ivermectin at 500 microg/kg.
- To assess the duration of action against induced infections of O. ostertagi, T. axei, and D. viviparus in calves.
Main Methods:
- Calves were experimentally infected with O. ostertagi, T. axei, and D. viviparus.
- Topical ivermectin at a dosage of 500 microg/kg was administered.
- Anthelmintic activity and efficacy were assessed over time.
Main Results:
- Topical ivermectin exhibited highly significant (P<0.001) anthelmintic activity.
- Efficacies exceeding 99% were observed against O. ostertagi and T. axei for at least 14 days.
- An efficacy of 98% was maintained against D. viviparus for at least 28 days.
Conclusions:
- Topical ivermectin at 500 microg/kg provides a persistent anthelmintic effect in calves.
- The treatment is highly effective against key gastrointestinal and lungworm parasites for prolonged periods.