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Related Experiment Videos

Persistent anthelmintic activity of abamectin injection in cattle.

J S Eagleson1, P G Scott, S J Gross

  • 1Merck and Co. Inc., PO Box 2000, Rahway, NJ 07065, United States.

New Zealand Veterinary Journal
|March 1, 1992
PubMed
Summary

Abamectin administered subcutaneously at 200 microg/kg showed high efficacy against cattle parasites when given 7 or 10 days before infection. However, anthelmintic activity was significantly reduced when administered 14 days prior.

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Area of Science:

  • Veterinary Parasitology
  • Pharmacology
  • Animal Health

Background:

  • Gastrointestinal nematodes pose a significant threat to cattle health and productivity.
  • Abamectin is a widely used anthelmintic, but its optimal administration timing for sustained efficacy requires further investigation.
  • Understanding the duration of anthelmintic activity is crucial for effective parasite control programs in cattle.

Purpose of the Study:

  • To determine the duration of anthelmintic activity of abamectin in cattle.
  • To evaluate the efficacy of abamectin against key gastrointestinal nematode species at different pre-infection treatment intervals.
  • To establish optimal treatment timing for abamectin to ensure maximum efficacy.

Main Methods:

  • Induced infections of Haemonchus placei, Ostertagia ostertagi, Cooperia spp., and Oesophagostomum radiatum were used in Friesian calves.

Related Experiment Videos

  • Calves were assigned to four groups: one control and three treated with abamectin (200 microg/kg subcutaneously) 14, 10, or 7 days before infection.
  • Efficacy was assessed by worm counts at slaughter, 50-52 days post-treatment and 36-38 days post-infection.

    • Main Results:

    • Abamectin demonstrated high efficacy (>98-99%) against all tested parasite species when administered 7 and 10 days before infection.
    • No significant anthelmintic activity was observed when abamectin was administered 14 days prior to infection.
    • The duration of effective anthelmintic activity for subcutaneous abamectin at 200 microg/kg was found to be less than 14 days in this study.

    Conclusions:

    • Subcutaneous administration of abamectin at 200 microg/kg provides effective control of Haemonchus placei, Ostertagia ostertagi, Cooperia spp., and Oesophagostomum radiatum in cattle when given 7 to 10 days before infection.
    • Treatment administered 14 days before infection showed minimal efficacy, suggesting a limited duration of action for abamectin under these conditions.
    • These findings highlight the importance of precise timing for abamectin treatment to maximize its anthelmintic effect and support sustainable parasite management in cattle herds.