Evaluation of a new linker system cleaved using samarium(II) iodide. Application in the solid phase synthesis of
Fiona McKerlie1, Iain M Rudkin, Graham Wynne
1Department of Chemistry, Joseph Black Building, University of Glasgow, Glasgow, UK G12 8QQ.
Organic & Biomolecular Chemistry
|July 21, 2005
Abstract:
A new linker design for solid phase synthesis has been developed that is cleaved under mild, neutral conditions using samarium(II) iodide. The feasibility of the linker approach has been illustrated in the solid phase synthesis of ketones and amides using an oxygen linker. Insights into the mechanism of the samarium(II) iodide cleavage reaction are described and the potential of a sequential cleavage carbon-carbon bond forming process is assessed.
