Related Experiment Video
Updated: Aug 16, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
Published on: May 3, 2018
The influence of circadian blood pressure changes on aortic distensibility and left ventricular diastolic function in
Dogan Erdogan1, Hakan Gullu, Mustafa Caliskan
1Cardiology Department, Konya Teaching and Medical Research Center, Baskent University, Selcuklu, Konya, Turkey. aydoganer@yahoo.com
Insights
Non-dipper hypertension, characterized by a lack of nighttime blood pressure decrease, showed similar left ventricular diastolic function compared to dipper hypertension. However, subtle, non-significant impairments in aortic elastic properties were observed in non-dippers.
Area of Science:
- Cardiology
- Hypertension Research
- Vascular Physiology
Background:
- Non-dipper hypertension is linked to increased cardiovascular risks and left ventricular structural changes.
- The impact of non-dipper blood pressure on aortic elasticity and diastolic function remains understudied.
Purpose of the Study:
- To investigate the effects of non-dipper blood pressure on aortic elastic properties.
- To assess left ventricular diastolic function in non-dipper hypertensive individuals.
Main Methods:
- Echocardiography (standard and tissue Doppler) was used to evaluate 22 non-dipper and 15 dipper hypertensive subjects.
- Aortic elastic properties and left ventricular diastolic function were assessed.
- Subjects had no systemic diseases or cardiovascular risk factors besides hypertension.
Main Results:
- No significant differences in left ventricular diastolic parameters were found between non-dipper and dipper groups.
- Aortic distensibility was slightly lower, and aortic stiffness index and elastic modulus were higher in the non-dipper group.
- These observed differences in aortic properties did not reach statistical significance.
Conclusions:
- Left ventricular remodeling and diastolic function are comparable between non-dipper and dipper hypertensive patients.
- Non-dipper hypertension may be associated with slight, though not statistically significant, impairments in aortic elastic properties.
Background:
Failure to decrease blood pressure (BP) normally during nighttime, which is called non-dipper, in hypertensive individuals is associated with higher cardiovascular morbidity and mortality. In addition, non-dipper BP leads to structural changes in the left ventricle; however, the influences of non-dipper BP on aortic elastic properties and left ventricular diastolic function have not been studied yet.
Methods:
In this study, we evaluated aortic elastic properties and left ventricular diastolic function of 22 subjects with non-dipper hypertension, and 15 subjects with dipper hypertension using transthoracic second harmonic standard and tissue Doppler echocardiography (Acuson Sequoia C256). None of the subjects had any systemic disease or coronary risk factor except hypertension.
Results:
Age, gender, body mass index, lipids, and standard echocardiographic findings including left ventricular mass index were similar between the groups. Office BP recordings were similar between non-dipper and dipper groups (147.9+/-6.1/93.9+/-4.3 vs. 144.0+/-8.0/93.0+/-3.7). Daytime and 24-h ambulatory BP measurements were similar within the groups, but nighttime BPs were significantly greater in non-dipper group than those were in dipper group. Left ventricular diastolic parameters obtained by both standard and tissue Doppler did not differ between the non-dipper and dipper groups. However, aortic distensibility was found to be slightly lower (4.1+/-2.4 vs. 4.9+/-1.9, p=0.08), and aortic stiffness index (6.3+/-0.5 vs. 6.1+/-0.4, p=0.08) and elastic modulus (6.2+/-2.5 vs. 4.8+/-2.3, p=0.08; groups non-dipper and dipper respectively) higher in non-dipper group than in dipper group. However, these differences were not statistically significant.
Conclusion:
Left ventricular remodeling and diastolic function were similar in patients with non-dipper and dipper hypertension. However, aortic elastic properties were slightly impaired in non-dipper hypertensives than those were in dipper ones, but these differences did not reach statistically significance.
Related Concept Videos
Factors affecting Blood pressure
Physiological Factors:
Hypertension and Regulation of Blood Pressure
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Hypertension III: Clinical Manifestations and Diagnostic Studies
Sites for measuring blood pressure
The Brachial Artery: Primary Site for Blood Pressure Measurement
