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Related Concept Videos

Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

1.1K
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
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Relaxation of Skeletal Muscles01:29

Relaxation of Skeletal Muscles

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The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
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Centrally Acting Muscle Relaxants: Therapeutic Uses01:24

Centrally Acting Muscle Relaxants: Therapeutic Uses

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Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
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Peripherally and Centrally Acting Muscle Relaxants: A Comparison01:09

Peripherally and Centrally Acting Muscle Relaxants: A Comparison

4.8K
Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
4.8K
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

1.3K
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
1.3K
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

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Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
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Related Experiment Video

Updated: Mar 15, 2026

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.6K

Relaxin (Connetics/Celltech).

R Jones1

  • 1Trinity Cottage, Killiney Hill Road, Killiney, Co Dublin, Ireland. JonesR@iconirl.com

Idrugs : the Investigational Drugs Journal
|July 21, 2005
PubMed
Summary
This summary is machine-generated.

Relaxin, a peptide hormone, shows promise in treating infertility and improving blood flow to oxygen-deprived tissues. Further research is exploring its potential for organ fibrosis and wound healing applications.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Regenerative Medicine

Background:

  • Relaxin, a peptide hormone from the insulin family, regulates connective tissue turnover.
  • It is under development for infertility and labor complications.
  • Previous development for scleroderma was discontinued due to trial results.

Purpose of the Study:

  • To evaluate relaxin's potential in treating organ fibrosis and infertility.
  • To assess relaxin's ability to induce angiogenesis and treat ischemic conditions.
  • To investigate relaxin's efficacy in healing non-healing ulcers.

Main Methods:

  • Preclinical studies assessing organ fibrosis and infertility.
  • Evaluating systemic administration for angiogenesis induction.
  • Animal models with impaired blood flow and diabetes for wound healing studies.

Main Results:

  • Relaxin significantly increased blood vessel growth at ischemic sites.
  • Systemic administration did not increase VEGF in non-wound cells.
  • Relaxin stimulated wound healing in animals with impaired blood flow or diabetes.

Conclusions:

  • Relaxin shows potential for treating ischemic conditions.
  • It may be effective for non-healing ulcers by improving blood flow.
  • Further research is warranted for its therapeutic applications in connective tissue diseases and wound healing.