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Updated: Aug 6, 2026
14:52
Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
Published on: December 11, 2013
Ankle-brachial index and peripheral arterial disease
C Lamina1, C Meisinger, I M Heid
1GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany.
Gesundheitswesen (Bundesverband Der Arzte Des Offentlichen Gesundheitsdienstes (Germany))
|July 21, 2005
Summary
Peripheral arterial disease patients face high cardiovascular risks. Identifying genetic and biochemical factors like apolipoprotein A-IV is crucial for managing these systemic complications.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Epidemiology
Background:
- Peripheral arterial disease (PAD), including intermittent claudication, presents significant risks for cardiovascular and cerebrovascular events.
- Patient outcomes are primarily determined by systemic vascular complications rather than local leg issues.
- Approximately 30% of these patients experience mortality within 5 years, with vascular events accounting for three-quarters of deaths.
Purpose of the Study:
- To identify biochemical and genetic risk factors for peripheral arterial disease.
- To investigate the role of anti-atherogenic apolipoprotein A-IV in PAD development and progression.
Main Methods:
- Utilizing data from the KORA Study 2004/2005 (F3), a follow-up to the MONICA Survey 1994/95 (S3).
- Performing analyses to identify potential biochemical and genetic markers associated with PAD.
Main Results:
- Analysis ongoing to identify specific biochemical and genetic risk factors.
- Apolipoprotein A-IV is being investigated as a potential anti-atherogenic factor.
Conclusions:
- Understanding risk factors is essential for improving outcomes in PAD patients.
- Further research into apolipoprotein A-IV may offer new therapeutic targets.
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