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Sleepwalking associated with hyperthyroidism.

Kamel M Ajlouni1, Azmi T Ahmad, Mohamed M El-Zaheri

  • 1National Center for Diabetes, Endocrinology and Genetics, Amman 11942, Jordan.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|July 22, 2005
PubMed
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Thyrotoxicosis, particularly Graves' disease, may cause new-onset sleepwalking in adults. Resolving hyperthyroidism often resolves sleepwalking, suggesting a direct link.

Area of Science:

  • Endocrinology
  • Sleep Medicine
  • Neurology

Background:

  • Hyperthyroidism, a condition of excess thyroid hormone, can manifest with diverse symptoms.
  • Sleepwalking (somnambulism) is typically associated with other conditions and rarely linked to endocrine disorders.

Observation:

  • This study reports eight cases of adult-onset sleepwalking coinciding with new-onset thyrotoxicosis.
  • The sleepwalking episodes resolved upon successful treatment of hyperthyroidism and recurred with poor disease control.

Findings:

  • A direct causal relationship between thyrotoxicosis and sleepwalking is suggested.
  • This association was specifically observed in patients with diffuse toxic goiter (Graves' disease), not other causes of hyperthyroidism.

Implications:

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  • Clinicians should consider screening for thyrotoxicosis in adults presenting with new-onset sleepwalking.
  • Further research is warranted to elucidate the pathophysiological mechanisms and prevalence of this association.