Related Experiment Video
Updated: Aug 16, 2026

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
Biochemical response to colloidal bismuth subcitrate: dose-time effect
Hasan Türkez1, Fatime Geyikoğlu, M Sait Keleş
1Department of Biology, Faculty of Arts and Sciences, Medical Faculty, Atatürk University, 25240, Erzurum, Turkey.
Abstract:
In the present study, an investigation was undertaken to assess the efficacy on serum enzymes of colloidal bismuth subcitrate (CBS). CBS was administered with injections to male rats in 100-, 200-, 400-, 500-, and 1000-microg/L doses of bismuth. Rats were anesthetized at different intervals (24, 48, and 72 h) after CBS injections. The levels of serum enzymes were determined. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and creatine kinase (CK) levels significantly increased after all CBS treatments without dependence on time. All doses of bismuth significantly affected the lactate dehydrogenase (LDH) in serum after 72 h. The lowest doses were the most toxic on ALT and LDH. These data suggest that treatment with CBS can provide evidence for a possible marker of liver toxicity although there is no evidence of liver accumulation of bismuth in the present study.
More Related Videos
Related Concept Videos
Measurement of Bioavailability: Pharmacodynamic Methods
Dose Response Curve: Conventional Versus Nonmonotonic
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship
Modified-Release Drug Delivery Systems: Bioavailability
Bioavailability Study Design: Single Versus Multiple Dose Studies

