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Published on: November 20, 2015
A primer on Apnea of prematurity
1Inova Fairfax Hospital for Children, Falls Church, VA 22042, USA. Stokowski@cox.net
Insights
Apnea of prematurity, a common respiratory issue in preterm infants, stems from immature systems. Management includes stimulation, medication, and respiratory support, with most infants improving by term corrected age.
Area of Science:
- Neonatology
- Pediatric Pulmonology
- Developmental Physiology
Background:
- Apnea, or cessation of breathing, frequently affects preterm infants shortly after birth.
- It arises from immature central nervous system and pulmonary system development.
- Apnea of prematurity is a diagnosis of exclusion, requiring differentiation from other serious conditions.
Purpose of the Study:
- To provide a comprehensive overview of apnea of prematurity.
- To discuss the underlying mechanisms, clinical management, and emerging therapies.
- To review long-term neurodevelopmental impacts and nursing care strategies.
Main Methods:
- Literature review of anatomic, physiological, and developmental factors.
- Analysis of standard and investigational treatment modalities.
- Examination of evidence on neurodevelopmental outcomes and nursing interventions.
Main Results:
- Apnea of prematurity is multifactorial, linked to immaturity.
- Standard treatments include stimulation, methylxanthines, and respiratory support.
- Investigational therapies and long-term impacts are under review.
Conclusions:
- Apnea of prematurity typically resolves as infants approach term corrected gestational age.
- Management strategies are tailored to infant needs, including home monitoring.
- Parent education is crucial for successful discharge and home care.
Abstract:
Apnea, the cessation of respiratory airflow, can begin in many preterm infants in the first week of life and can last until the day of discharge or beyond. This article provides an overview of the complex anatomic, physiological, and developmental mechanisms related to immaturity of both the central nervous system and musculature of the pulmonary system, that contribute to apnea of prematurity. Apnea of prematurity is a diagnosis of exclusion; an array of other conditions and stimuli can also cause apnea, including infections, pulmonary disease, and intracranial pathology. The standard clinical management of apnea, including cutaneous stimulation, methylxanthine therapy, and continuous positive airway pressure or ventilatory support, are discussed as well as newer investigational therapies, such as olfactory stimulation. Emerging evidence on the long-term neurodevelopmental impact of apnea is reviewed. Nursing measures to prevent and manage apnea are reviewed with an emphasis on parent education and preparation for discharge. Apnea resolves in most preterm infants as they approach term corrected gestational age; however, if it does not, options include continued hospitalization or, for infants with stable apnea, discharge with a home apnea monitor.
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