Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluoroquinolones for treating tuberculosis.

L E Ziganshina1, A A Vizel, S B Squire

  • 1Clinical Pharmacology and Pharmacotherapy, Kazan State Medical Academy for Postgraduate Medical Education, 11 Mushtari Street, 420012, 14-15 Malaya Krasnaya Street, 420015, Kazan, Tatarstan, Russia, 420012. lezign@hotmail.com

The Cochrane Database of Systematic Reviews
|July 22, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A combined tropical medicine and psychiatry approach to patients with possible delusional infestation.

Transactions of the Royal Society of Tropical Medicine and Hygiene·2024
Same author

Pooling sputum samples for Xpert® MTB/RIF and Xpert® Ultra testing for TB diagnosis.

Public health action·2023
Same author

[Problems and opportunities to improve diagnosis of asthma and chronic obstructive pulmonary disease in Russia: resolution of advisory board].

Terapevticheskii arkhiv·2022
Same author

Resource use during systematic review production varies widely: a scoping review: authors' reply.

Journal of clinical epidemiology·2021
Same author

Resource use during systematic review production varies widely: a scoping review.

Journal of clinical epidemiology·2021
Same author

[The concept of chronic obstructive pulmonary disease clinical control as a decision - making tool in real clinical practice for optimizing of basic pharmacotherapy].

Terapevticheskii arkhiv·2020
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Fluoroquinolones like ciprofloxacin and ofloxacin show no significant difference in treating tuberculosis. Ciprofloxacin use in drug-sensitive tuberculosis may increase relapse, especially in HIV-positive individuals.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Clinical Trials

Background:

  • Fluoroquinolones are utilized in treating multidrug-resistant and drug-sensitive tuberculosis.
  • The efficacy and safety of fluoroquinolones in tuberculosis treatment regimens require thorough evaluation.

Purpose of the Study:

  • To systematically assess the role of fluoroquinolones as supplementary or alternative agents in antitubercular drug regimens.
  • This evaluation encompasses both drug-sensitive and drug-resistant forms of tuberculosis.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases, including Cochrane, MEDLINE, EMBASE, LILACS, Science Citation Index, and Russian databases, up to April 2005.
  • Randomized controlled trials (RCTs) involving antitubercular regimens with fluoroquinolones for bacteriologically confirmed pulmonary tuberculosis were included.

Related Experiment Videos

  • Data extraction and quality assessment were performed independently by two authors, with statistical analysis using relative risk and weighted mean difference.

    • Main Results:

    • Ten trials with 1178 participants were analyzed. No significant differences in cure, treatment failure, or clinical improvement were observed when substituting ciprofloxacin or ofloxacin for first-line drugs.
    • Ciprofloxacin substitution in drug-sensitive tuberculosis was linked to increased relapse rates and longer sputum culture conversion times, particularly in HIV-positive participants.
    • Levofloxacin addition or substitution showed no impact in drug-resistant tuberculosis, and sparfloxacin did not differ significantly from ofloxacin in cure, failure, or adverse events.

    Conclusions:

    • Current evidence from RCTs is limited to ciprofloxacin, ofloxacin, levofloxacin, and sparfloxacin for tuberculosis treatment.
    • Ciprofloxacin is not recommended for tuberculosis treatment based on the available data.
    • Further trials investigating newer fluoroquinolones for tuberculosis are necessary, and no superiority of sparfloxacin over ofloxacin was demonstrated in drug-resistant tuberculosis.