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Related Experiment Videos

The case for prepatterning in the mouse.

Richard L Gardner1

  • 1Mammalian Development Laboratory, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom. richard.gardner@zoology.ox.ac.uk

Birth Defects Research. Part C, Embryo Today : Reviews
|July 22, 2005
PubMed
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Early mammalian development shows nonrandom patterns in the zygote and two-cell conceptus, suggesting prepatterning rather than solely cell interactions. This indicates intrinsic organization may play a role before fertilization.

Area of Science:

  • Developmental biology
  • Cell biology
  • Embryology

Background:

  • Early embryonic development in mammals is thought to rely on blastomere interactions.
  • Blastomeres are widely considered equipotential until the eight-cell stage.
  • Patterning of the blastocyst is crucial for subsequent development.

Purpose of the Study:

  • To investigate the nonrandom mapping of early conceptus features onto the blastocyst.
  • To explore the role of prepatterning in mammalian embryonic development.
  • To determine the contribution of oocyte organization versus fertilization events to early patterning.

Main Methods:

  • Analysis of zygote and two-cell conceptus features.
  • Utilizing various laboratory techniques across multiple studies.

Related Experiment Videos

  • Mapping of features onto the blastocyst's axis of polarity and bilateral plane.

    • Main Results:

    • Features of the zygote and two-cell conceptus map nonrandomly on the blastocyst.
    • This nonrandom mapping contradicts the equipotential blastomere model.
    • Evidence suggests prepatterning is a normal aspect of mammalian development.

    Conclusions:

    • Mammalian development likely involves prepatterning, not solely post-fertilization interactions.
    • The extent of oocyte's intrinsic organization in prepatterning requires further investigation.
    • Distinguishing between oocyte organization and fertilization-dependent events is key.