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[Diabetic gastroparesis].

M P Stassen1

  • 1Clinique A. Renard, Herstal.

Revue Medicale De Liege
|July 23, 2005
PubMed
Summary
This summary is machine-generated.

Diabetic gastroparesis, a complication affecting 50% of diabetics, involves delayed stomach emptying impacting blood sugar control. Limited treatments exist, but lifestyle changes and certain medications may offer relief.

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Diabetology

Context:

  • Diabetic gastroparesis is a common complication in 50% of type 1 and type 2 diabetes patients.
  • It involves delayed gastric emptying due to autonomic neuropathy, affecting quality of life and glycemic control.
  • Blood glucose levels directly influence gastric motility, with hyperglycemia slowing and hypoglycemia accelerating emptying.

Purpose:

  • To review the pathophysiology, diagnosis, and management of diabetic gastroparesis.
  • To highlight the impact of gastroparesis on glycemic control and drug absorption.
  • To discuss current and potential treatment strategies for this condition.

Summary:

  • Diabetic gastroparesis is characterized by delayed gastric emptying without mechanical obstruction, often linked to autonomic neuropathy.

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  • Diagnosis is confirmed via gastric emptying scintigraphy. Treatment involves lifestyle modifications and pharmacotherapy (e.g., metoclopramide, domperidone, cisapride, erythromycin).
  • Cisapride, while effective, carries cardiac risks. Gastroparesis can cause erratic glucose levels, but intensive insulin therapy and prokinetics may improve glycemic control.

    • Impact:

    • Understanding diabetic gastroparesis is crucial for managing diabetes complications and improving patient outcomes.
    • Effective management can lead to better glycemic control and enhanced quality of life.
    • Further research into safer and more effective treatments is warranted.