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Mouse behavioural analysis in systems biology.

Peter Van Meer1, Jacob Raber

  • 1Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97239, USA.

The Biochemical Journal
|July 23, 2005
PubMed
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This review explores using molecular techniques in mice to study gene function and behavior. It details common mouse models and behavioral tests, highlighting histaminergic neurotransmission

Area of Science:

  • Neuroscience
  • Genetics
  • Behavioral Science

Background:

  • In vivo gene expression modulation offers insights into gene and biological system functions.
  • The laboratory mouse (Mus musculus) is a preferred model due to genetic and behavioral similarities to humans.
  • Behavioral studies require careful consideration of both genetic and environmental factors.

Purpose of the Study:

  • To review common mouse models for behavioral analyses.
  • To discuss considerations for designing and interpreting behavioral experiments.
  • To illustrate the application of behavioral tests in understanding histaminergic neurotransmission.

Main Methods:

  • Description of common mouse models for behavioral studies.
  • Discussion of experimental design and interpretation factors.

Related Experiment Videos

  • Review of standard behavioral tests for assessing brain function.

    • Main Results:

    • Mice serve as a valuable model for behavioral genetics research.
    • Genetic and environmental interactions significantly impact behavioral outcomes.
    • Behavioral tests are crucial for elucidating the role of neurotransmission in brain function.

    Conclusions:

    • Molecular techniques enhance in vivo gene expression studies in mice.
    • Rigorous experimental design is essential for valid behavioral research.
    • Behavioral testing provides a framework for understanding neurobiological mechanisms, such as histaminergic pathways.