Use of sublingual buprenorphine for pain relief in office hysteroscopy

To assess the efficacy of sublingual buprenorphine in the relief of pain associated with office hysteroscopy.

Prospective, randomized study (Canadian Task Force classification I).

Tertiary medical center.

One hundred sixty-four women referred for office hysteroscopy from September 2003 through March 2004.

Before hysteroscopy, 80 women received a tablet of buprenorphine (group A), and 84 women received a placebo (group B). Their pain sensations were evaluated on a 10-cm visual analog scale, and they were asked about the adverse reactions and level of satisfaction on the following day.

The pain score in group A was 3.3 +/- 1.1, which was similar to 3.2 +/- 1.3 in group B. The pain scores in subgroups of women also were similar within the same group and between the two groups. Thirty-one women (38.8%) in group A reported adverse reactions, including nausea, vomiting, and drowsiness, while none in group B reported any adverse reactions.

Office hysteroscopy with a 3.1-mm flexible hysteroscope is a well-tolerated procedure. Sublingual buprenorphine is not helpful in relieving the pain associated with hysteroscopy but is associated with significant adverse reactions.