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Related Experiment Videos

Ectopic pregnancy with postcoital contraception--a case report.

A Basu1, Ck Candelier

  • 1Department of Obstetrics and Gynecology, Stepping Hill Hospital, Stockport, Cheshire, UK.

The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception
|July 23, 2005
PubMed
Summary

Ectopic pregnancy risk increases with Levonelle-2 use. This emergency contraceptive may delay embryo transfer, potentially causing ectopic pregnancy even without prior risk factors.

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Area of Science:

  • Reproductive Endocrinology
  • Pharmacology

Background:

  • Ectopic pregnancy incidence is rising, with known risk factors including tubal pathology and prior ectopic pregnancy.
  • Levonelle-2 (progesterone-only emergency contraceptive) prevents pregnancy via ovulation inhibition, fertilization prevention, and implantation inhibition.
  • While 85% effective, 12 UK cases of ectopic pregnancy with Levonelle-2 use have been reported.

Observation:

  • A case study details a woman with an ectopic pregnancy following Levonelle-2 use.
  • The patient presented with no identifiable clinical predisposing risk factors for ectopic pregnancy.
  • No histological evidence of tubal damage was found.

Findings:

  • Progesterone is thought to slow intratubal migration of fertilized ova.
  • The levonorgestrel in Levonelle-2 is suspected to cause delayed embryo transfer.

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  • This delay is hypothesized to be the cause of the ectopic pregnancy in this case.

    • Implications:

    • This case suggests a potential mechanism for Levonelle-2-associated ectopic pregnancy.
    • Further research is warranted to confirm levonorgestrel's role in delayed embryo transport.
    • Clinicians should consider this possibility in patients presenting with ectopic pregnancy after emergency contraceptive use.