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Updated: Aug 16, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Scorpion venom peptides without disulfide bridges
Xian-Chun Zeng1, Gerardo Corzo, Richard Hahin
1Department of Biotechnology, Key Laboratory of MOE for Virology, Institute of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, P. R. China. zengx@mail.nih.gov
Abstract:
Several hundred disulfide-bridged neurotoxic peptides have been characterized from scorpion venom; however, only few scorpion venom peptides without disulfide bridges have been identified and characterized. These non-disulfide-bridged peptides (NDBPs) are a novel class of molecules because of their unique antimicrobial, immunological or cellular signaling activities. This review provides an overview of their structural simplicity, precursor processing, biological activities and evolution, and sheds insight into their potential clinical and agricultural applications. Based on their pharmacological activities and peptide size similarity, we have classified these peptides into six subfamilies.
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