Related Experiment Video
Updated: Jan 12, 2026
06:18
Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
Published on: December 6, 2024
983
LDL-cholesterol predicts negative coronary artery remodelling in diabetic patients: an intravascular ultrasound study
Pilar Jiménez-Quevedo1, Manel Sabaté, Dominick Angiolillo
1Interventional Cardiology Unit, Cardiovascular Institute, Hospital Clínico San Carlos, C/Prof. Martín Lagos s/n, 28040 Madrid, Spain.
European Heart Journal
|July 23, 2005
Summary
Diabetic patients frequently exhibit negative coronary artery remodelling, characterized by vessel shrinkage. This condition is significantly associated with elevated low-density lipoprotein cholesterol (LDL-C) levels.
Area of Science:
- Cardiology
- Diabetology
- Vascular Biology
Background:
- Diabetic patients have a higher risk of cardiovascular disease.
- Coronary artery remodelling plays a role in the progression of atherosclerosis.
Purpose of the Study:
- To examine the link between coronary artery remodelling and metabolic profiles in diabetic individuals.
- To identify predictors of coronary artery remodelling in this population.
Main Methods:
- Intravascular ultrasound was used to analyze 131 coronary lesions in 80 diabetic patients.
- The remodelling index (RI) was calculated, with RI<1 indicating negative remodelling (vessel shrinkage).
- Statistical analyses, including correlation and multivariable regression, were performed.
Main Results:
- Coronary artery shrinkage (negative remodelling) was observed in 71.7% of lesions.
- The remodelling index showed significant inverse correlations with total cholesterol, apolipoprotein-B, and LDL-cholesterol.
- LDL-cholesterol was identified as the sole independent predictor of the remodelling index.
Conclusions:
- Negative coronary artery remodelling is common in diabetic patients.
- Elevated LDL-cholesterol levels are associated with negative remodelling.
- This association may contribute to the diffuse coronary artery disease seen in diabetes.
Related Concept Videos
01:26Atherosclerosis III: Management
293
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
293
01:30Coronary Artery Disease I: Introduction
847
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
847
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
370
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
370
01:30Acute Coronary Syndrome III: Diagnostic Studies
197
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
197
01:26Coronary Artery Disease IV: Preventive Measures
572
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
572