Related Experiment Video
Updated: Jul 18, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
Behavioral manifestations associated with multiple sclerosis
1Neurobehavior Program, Brentwood Division, West Los Angeles Department of Veterans Affairs Medical Center, California.
Abstract:
The behavioral manifestations associated with MS include both cognitive and emotional disturbances. Overall intellect is slightly affected in about half of patients, and 20% to 33% demonstrate more severe impairments. Memory disturbances are particularly common, and retrieval function is especially affected. Difficulties with concept formation and other executive functions can be subtle yet have significant impact on daily living. Depression is frequent in MS, sometimes despite an outward euphoria that is more prevalent with advancing disease. Psychosis occurs rarely, but bipolar disorder is more frequent than in the general population. MS may be associated with a variety of personality changes, but it is impossible to generalize about this or to identify an "MS personality." Disturbances of emotional control are relatively frequent. Comprehensive management of these problems uses multiple modalities including good neurologic care, cognitive rehabilitation, counseling and support groups, and pharmacotherapy.
Insights
Multiple Sclerosis (MS) significantly impacts cognition and emotion, affecting intellect, memory, and executive functions. Management requires a multimodal approach including neurologic care, rehabilitation, and therapy.
Area of Science:
- Neurology
- Neuropsychology
Background:
- Multiple Sclerosis (MS) is a chronic neurological disease.
- Behavioral changes, including cognitive and emotional disturbances, are common in MS patients.
Purpose of the Study:
- To summarize the range of behavioral manifestations in Multiple Sclerosis.
- To highlight the impact of these changes on daily living and management strategies.
Main Methods:
- Literature review of studies on cognitive and emotional changes in MS.
- Analysis of reported prevalence and severity of impairments.
Main Results:
- Cognitive impairments affect intellect (50%) and executive functions in MS patients.
- Memory retrieval, concept formation, and emotional control disturbances are prevalent.
- Depression is frequent, with occasional euphoria; psychosis is rare but bipolar disorder is more common.
Conclusions:
- Behavioral disturbances are integral to Multiple Sclerosis, impacting quality of life.
- Comprehensive management integrating neurologic care, cognitive rehabilitation, counseling, and pharmacotherapy is essential.
Related Concept Videos
Parkinson's Disease: Overview
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Multiple Sclerosis l: Introduction
Parkinson Disease l: Introduction
Alterations in Muscle Tone ll
Alterations in Muscle Tone lll

