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Sprint training improves postischemic, left ventricular diastolic performance.

Joseph R Libonati1, Zebulon V Kendrick, Steven R Houser

  • 1Department of Kinesiology, Temple University, Philadelphia, PA 19122, USA. jlibonat@temple.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 23, 2005
PubMed
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Sprint training improves heart function by reducing left ventricular stiffness after ischemia-reperfusion injury. This protection is linked to enhanced glycolysis, not calcium handling, in sprint-trained hearts.

Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Ischemia-Reperfusion Injury

Background:

  • Left ventricular (LV) diastolic dysfunction is a significant consequence of ischemia-reperfusion (I/R) injury.
  • The role of exercise, particularly high-intensity sprint training, in mitigating I/R-induced cardiac stiffness remains incompletely understood.

Purpose of the Study:

  • To investigate the effects of a 6-week high-intensity sprint training program on LV diastolic stiffness.
  • To determine if sprint training offers protection against I/R-induced diastolic dysfunction in isolated rat hearts.

Main Methods:

  • Male Sprague-Dawley rats were assigned to either a sedentary control group or a sprint-trained group.
  • Sprint training involved 5 weekly sessions of high-intensity interval running.

Related Experiment Videos

  • Langendorff-perfused hearts were assessed for LV performance and stiffness before and after I/R, with myocyte function analyzed subsequently.

    • Main Results:

    • Sprint training significantly reduced LV chamber stiffness under both normoxic and post-I/R conditions.
    • Sprint-trained hearts exhibited better preservation of LV developed pressure after I/R, attributed to lower diastolic stiffness.
    • Glycolytic inhibition abolished the protective effect of sprint training, implicating glycolysis in the observed benefits.

    Conclusions:

    • High-intensity sprint training effectively reduces LV diastolic stiffness and improves recovery from I/R injury.
    • Sprint-induced cardioprotection against I/R appears to be mediated, in part, by enhanced cardiac glycolysis.
    • Mechanisms beyond calcium handling contribute to the beneficial effects of sprint training on post-ischemic cardiac function.