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'Designer drugs'. Recognizing and managing their toxic effects.

G L Sternbach1, J Varon

  • 1Emergency Medicine Service, Stanford University Medical Center, CA 94305.

Postgraduate Medicine
|June 1, 1992
PubMed
Summary

Designer drugs, like "Adam" and "Eve," are illicit substances created to mimic controlled drugs, posing significant health risks. This review covers their clinical effects and management strategies for intoxication.

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Area of Science:

  • Toxicology
  • Emergency Medicine
  • Pharmacology

Background:

  • Designer drugs are illicit substances synthesized to bypass legal controls and produce specific psychoactive effects.
  • Their use and abuse can result in severe medical complications, including fatalities.

Purpose of the Study:

  • To review the most prevalent designer drugs currently encountered.
  • To outline the clinical manifestations of intoxication from these substances.
  • To discuss appropriate management strategies for designer drug overdose.

Main Methods:

  • Literature review of known designer drug compounds.
  • Analysis of clinical case reports and toxicological data.
  • Synthesis of information on clinical presentation and treatment protocols.

Main Results:

  • Identification of commonly abused designer drugs such as "Adam" (MDMA) and "Eve" (MDEA).
  • Description of characteristic signs and symptoms of intoxication, including altered mental status and physiological changes.
  • Discussion of supportive care and specific interventions for managing toxicity.

Conclusions:

  • Designer drug intoxication presents a significant public health challenge requiring prompt recognition and management.
  • Understanding the pharmacology and toxicology of these compounds is crucial for effective clinical care.
  • Continued vigilance and research are necessary to address the evolving landscape of designer drug abuse.

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