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Related Experiment Videos

SNAREs and traffic.

Wanjin Hong1

  • 1Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Sinapore, Singapore. mcbhwj@imcb.a-star.edu

Biochimica Et Biophysica Acta
|July 23, 2005
PubMed
Summary
This summary is machine-generated.

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) mediate vesicle transport and fusion in cells. This review details SNARE functions and mechanisms in mammalian systems.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Context:

  • Vesicle-mediated transport is crucial for cellular function.
  • Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are key regulators of vesicle docking and fusion.
  • SNARE function is conserved across species and cellular processes.

Purpose:

  • To review the key properties of SNAREs.
  • To elucidate the mechanism of action of SNAREs in mammalian cells.
  • To provide a comprehensive overview of SNAREs in the post-genomic era.

Summary:

  • SNAREs are essential proteins mediating the final steps of vesicle docking and fusion.
  • The SNARE machinery is conserved evolutionarily and mechanistically in eukaryotic cells.

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  • This review consolidates current knowledge on SNAREs in mammalian systems, including their properties and functions.

    • Impact:

    • Enhanced understanding of intracellular transport mechanisms.
    • Provides a foundation for further research into SNARE-related cellular processes.
    • Facilitates the study of diseases linked to vesicle transport defects.