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Updated: Aug 16, 2026

Imaging the Aging Cochlea with Light-Sheet Fluorescence Microscopy
Published on: September 28, 2022
The relationship of the round window membrane to the cochlear aqueduct shown in three-dimensional imaging
R Hofman1, J M Segenhout, F W J Albers
1Department of Otorhinolaryngology, University Hospital Groningen, The Netherlands. r.hofman@azg.kno.nl
Abstract:
The round window membrane and cochlear aqueduct complex in the guinea pig are reconstructed with 3D-imaging, using orthogonal plane fluorescence optical sectioning (OPFOS). The 3D-images show that the periotic duct and the aqueduct are connected to a pouch-like extension of the round window. The function of this may be regulation of aqueduct flow resistance under the influence of a pressure difference between inner ear fluid and middle ear.
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