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Postprandial increase of plasma apoAV concentrations in Type 2 diabetic patients
Valérie Pruneta-Deloche1, Gabriel Ponsin, Laure Groisne
1UMR 585 INSERM/INSA, Physiopathologie des Lipides et Membranes, Villeurbanne, France. valerie.pruneta-deloche@insa-lyon.fr
Abstract:
Postprandial hypertriglyceridemia is considered as a risk factor for cardiovascular disease in Type 2 diabetes. However, little is known about the underlying mechanisms. Since the recently discovered apolipoprotein (apo) AV was identified as a modulator of triglyceride (TG) metabolism, the aim of the study was to determine the postprandial apoAV profile of Type 2 diabetic patients. We compared data from 11 patients with Type 2 diabetes mellitus to that of 12 non-diabetic normolipidemic subjects following the ingestion of a lipid-rich cream. Postprandial apoAV was elevated in diabetic patients but no correlation was observed either with plasma TG concentration or with the intensity of lipoprotein lipase-dependent lipolysis. These data obtained in human subjects suggest that plasma apoAV concentration does not play an acute or a direct role in the regulation of plasma TG in the postprandial state.
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