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Updated: Jan 19, 2026

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
Published on: May 31, 2024
Macular thickness after cataract surgery with intracameral cefuroxime
Mamta S Gupta1, Hamish D R McKee, Manuel Saldaña
1Hull and East Yorkshire Eye Hospital, Hull, Yorkshire, UK. sgupta6502@aol.com
Purpose:
To determine whether the use of prophylactic intracameral cefuroxime during phacoemulsification cataract surgery is associated with increased macular thickening in the postoperative period.
Setting:
Hull and East Yorkshire Eye Hospital, Hull, United Kingdom.
Methods:
In this prospective randomized double-masked clinical study, the study group received 1 mg of intracameral cefuroxime and the control group received intracameral balanced salt solution only. Ocular coherence tomography was performed 5 (+/-1) weeks after surgery.
Results:
Intracameral cefuroxime did not have a statistically significant effect on postoperative macular thickness compared with nonadministration of intracameral antibacterials. All patients in both groups achieved a postoperative best corrected visual acuity of 6/9 or better.
Conclusion:
Use of 1 mg of intracameral cefuroxime was not associated with increased macular thickness 4 weeks to 6 weeks postoperatively.

