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Brain serotonin1A receptor binding in major depression is related to psychic and somatic anxiety
Gregory M Sullivan1, Maria A Oquendo, Norman Simpson
1Division of Neuroscience, Department of Psychiatry, New York 10032, USA. gms11@columbia.edu
Background:
The anxious phenotype of the 5-HT1A receptor knockout mouse and the anxiolytic properties of 5-HT1A agonists suggest that the 5-HT1A receptor modulates anxiety. We investigated the relationship of anxiety expressed in major depressive disorder (MDD) to regional 5-HT1A binding.
Methods:
Positron emission tomography with [carbonyl-11C]WAY-100635 was used to estimate regional 5-HT1A binding potential (BP) in 28 medication-free MDD subjects. Stepwise linear regression assessed the predictive capacity of three anxiety components, derived from a larger MDD sample and termed psychic, somatic, and motoric anxiety, on regional 5-HT1A BP.
Results:
Higher psychic (beta >or= .63) and lower somatic (beta
Conclusions:
The 5-HT1A receptor in the same brain regions has different relationships to psychic anxiety versus somatic anxiety. Lower 5-HT1A BP in panic disorder may be accounted for by higher somatic and lower psychic anxiety. Further study of the pathobiology of these anxiety components may identify distinct therapeutic targets or mechanisms.
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