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Male-mediated developmental toxicity.

Diana Anderson1

  • 1Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire, BD7 IDP, UK. d.anderson1@bradford.ac.uk

Toxicology and Applied Pharmacology
|July 26, 2005
PubMed
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Paternal exposure to certain agents can harm offspring, leading to infertility and cancer. Rodent studies confirm heritable effects from radiation and chemicals like cyclophosphamide, demonstrating transgenerational risks.

Area of Science:

  • Environmental Health
  • Toxicology
  • Genetics

Background:

  • Public awareness of male exposure risks to offspring is increasing.
  • Historical cases, like Seascale leukaemia, highlight potential paternal irradiation effects.
  • Experimental evidence in mice supports heritable impacts from radiation exposure.

Purpose of the Study:

  • To investigate transgenerational effects of male exposure to environmental agents.
  • To assess the potential for developmental abnormalities and tumors in offspring.
  • To evaluate genetic damage transmission across generations in rodent models.

Main Methods:

  • Utilizing an extended dominant lethal assay in rodent models.
  • Examining fetuses for skeletal malformations and performing karyotype analysis.

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  • Allowing litters to develop to adulthood to observe for tumors and genetic damage transmission.

    • Main Results:

    • Cyclophosphamide induced positive responses in all examined endpoints.
    • 1,3-butadiene showed positive responses in some endpoints, with heritable study results used for human risk assessment.
    • Urethane exposure resulted in liver tumors in the F(1) male offspring, suggesting independent genetic events.

    Conclusions:

    • Male exposure to agents like radiation, cyclophosphamide, 1,3-butadiene, and urethane can cause heritable adverse effects in offspring.
    • Rodent models are effective for studying transgenerational toxicity and genetic damage.
    • Findings support the need for risk assessment of paternal exposure to environmental hazards.