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Updated: Aug 16, 2026
A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
Published on: December 4, 2018
Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with
Marc C Levesque1, Youwei Chen, Bethany E Beasley
1Department of Medicine, Division of Rheumatology, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA. marc.levesque@duke.edu
Abstract:
B cell chronic lymphocytic leukemia (CLL) CD38 expression is variable and may predict outcome. Inducible nitric oxide synthase (NOS2) expression regulates CLL cell apoptosis. IL-4 and IFN-gamma regulate B cell CD38 expression and NOS2 expression. We compared IL-4 and IFN-gamma serum levels between CLL patients and normal individuals, and determined whether serum IL-4 and IFN-gamma levels correlated with CLL cell CD38 expression and NOS enzyme activity. IL-4 levels, but not IFN-gamma levels, differed between normal individuals and CLL patients. Furthermore, there was an association of IL-4 levels, but not IFN-gamma levels, with CD38 and NOS2 expression in CLL patients.
