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Updated: Aug 16, 2026

A Microphysiologic Platform for Human Fat: Sandwiched White Adipose Tissue
Published on: August 15, 2018
Hypothesis paper Brain talks with fat--evidence for a hypothalamic-pituitary-adipose axis?
A Schäffler1, N Binart, J Schölmerich
1Department of Internal Medicine I, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany. andreas.schaeffler@klinik.uni-regensburg.de
Abstract:
The adipose tissue signals to the brain via its secretory products. However, it is unknown whether the brain itself can directly contact the fat tissue. In order to test this hypothesis, the adipocytic expression of receptors for pituitary hormones and hypothalamic peptides was investigated. Besides FSH- and LH-receptors, adipocytes do express the specific receptors for ACTH, TSH, GH, prolactin, oxytocin and the three receptor subtypes for vasopressin. Thus, the adipose tissue might no longer be regarded as an inert and steady tissue but as a fast acting player downstream of and under the control of the brain. Based on this, the potential existence and clinical impact of a hypothalamic-pituitary-adipose axis should further be investigated.
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