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Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
'O-Acyl isopeptide method' for the efficient preparation of amyloid beta peptide 1-42 mutants
Youhei Sohma1, Yousuke Chiyomori, Maiko Kimura
1Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
Bioorganic & Medicinal Chemistry
|July 26, 2005
Abstract:
Novel water-soluble isopeptides of Abeta1-42 mutants, '26-O-acyl isoAbeta1-42 (26-AIAbeta42) mutants', which were efficiently converted to intact Abeta1-42 mutants with no byproduct formation under physiological conditions, were synthesized. These isopeptides provide a new system useful for investigating the biological function of Abeta1-42 mutants.
