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Sustained release of 5-fluorouracil from oil/water emulsions
M Ishikawa1, H Kikuta, A Imaizumi
1Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Research Communications in Chemical Pathology and Pharmacology
|May 1, 1992
Abstract:
Release profile of 5-fluorouracil (5-FU) from O/W emulsion and bone marrow toxicity of 5-FU to mice were compared with those of an aqueous solution of 5-FU. 5-FU emulsion had lower bone marrow toxicity and a slower drug release rate than the 5-FU aqueous solution which exhibited high bone marrow toxicity and fast drug release rate. A correlation between the rate of drug release and bone marrow toxicity was suggested.