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Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging.

Juergen Bardutzky1, Qiang Shen, Nils Henninger

  • 1Department of Neurology, University of Heidelberg, Heidelberg, Germany. juergen_bardutzky@med.uni-heidelberg.de

Stroke
|July 26, 2005
PubMed
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Differences in how Sprague-Dawley (SD) and Wistar-Kyoto (WK) rats develop ischemic lesions after middle cerebral artery occlusion (MCAO) are significant. These interstrain variations impact stroke research outcomes and therapeutic assessments.

Area of Science:

  • Neuroscience
  • Ischemic Stroke Research
  • Animal Models

Background:

  • Interstrain differences in rat models can affect experimental stroke research outcomes.
  • Middle cerebral artery occlusion (MCAO) is a common model for studying ischemic stroke.

Purpose of the Study:

  • To investigate the spatiotemporal evolution of ischemia in Sprague-Dawley (SD) and Wistar-Kyoto (WK) rats after permanent MCAO.
  • To compare diffusion and perfusion imaging findings between the two rat strains.

Main Methods:

  • Serial quantitative cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) measurements were performed up to 210 minutes post-MCAO.
  • Lesion volumes were calculated using viability thresholds and correlated with 24-hour infarct volumes (2,3,5-triphenyltetrazolium chloride staining).

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Main Results:

  • ADC-derived lesion volume growth differed significantly between SD and WK rats, with WK rats showing progressive growth over 210 minutes.
  • Abnormal perfusion volume strongly correlated with infarct size in both strains.
  • Diffusion/perfusion mismatch patterns varied, being more prolonged in WK rats compared to SD rats.

Conclusions:

  • Substantial differences exist in acute ischemic lesion evolution between SD and WK rats following MCAO.
  • These interstrain variations are critical considerations for evaluating therapeutic interventions in rat MCAO models.